Effect of somatostatin on circadian rhythms of firing and 2-deoxyglucose uptake in rat suprachiasmatic slices

T. Hamada, S. Shibata, A. Tsuneyoshi, K. Tominaga, S. Watanabe

研究成果: Article査読

30 被引用数 (Scopus)

抄録

In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus appears to act as a circadian clock. The SCN vasoactive intestinal polypeptide-like immunoreactive neurons, which may act to mediate photic information in the SCN, receive input from neurons immunoreactive for somatostatin (SST). Therefore we investigated the role of SST as a transmitter for entrainment by analyzing the phase-resetting effect of SST on the circadian rhythm of SCN firing activity. Perfusion of SST increased 2-deoxyglucose uptake at circadian time (CT) 18, but not at CT6. A 1-h or 15-min treatment with SST produced phase delays when it was administered at CT13-14 and phase advances at CT22-23. Thus SST-induced phase changes are similar to those for light pulses to animals under constant darkness. The present findings suggest that SST is a transmitter for mediating information of entrainment to circadian clocks within the SCN.

本文言語English
ページ(範囲)R1199-R1204
ジャーナルAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
265
5 34-5
DOI
出版ステータスPublished - 1993
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 生理学(医学)

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