Effect of surface charge of magnetite nanoparticles on their internalization into breast cancer and umbilical vein endothelial cells

Tetsuya Osaka*, Takuya Nakanishi, Sangaraju Shanmugam, Shintaro Takahama, Hong Zhang

*この研究の対応する著者

研究成果: Article査読

126 被引用数 (Scopus)

抄録

Internalization of magnetite nanoparticles with diameter of approximately 40 nm into normal and cancer cells was examined by microscopic observation and flow cytometry. Magnetite nanoparticles were synthesized by hydrolysis in an aqueous solution containing ferrous chloride with organic amines as a base. It was demonstrated that the difference in surface charge of magnetite nanoparticles brought about the difference in uptake efficiency. The nanoparticles with positive charge showed higher internalization into human breast cancer cells than the nanoparticles with negative charge, while the degree of internalization of the positively- and negatively-charged nanoparticles into human umbilical vein endothelial cells (HUVEC) was almost the same.

本文言語English
ページ(範囲)325-330
ページ数6
ジャーナルColloids and Surfaces B: Biointerfaces
71
2
DOI
出版ステータスPublished - 2009 7月 1

ASJC Scopus subject areas

  • バイオテクノロジー
  • 表面および界面
  • 物理化学および理論化学
  • コロイド化学および表面化学

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