Effect of surface coverage of gold(111) electrode with cysteine on the chiral discrimination of DOPA

Mariko Matsunaga, Takuya Nakanishi, Toru Asahi, Tetsuya Osaka*

*この研究の対応する著者

研究成果: Article査読

20 被引用数 (Scopus)

抄録

The enantioselectivity imparted to a gold electrode by modifying its surface with a self-assembled monolayer (SAM) of cysteine (Cys) was investigated for the electrochemical redox reaction of 3,4-dihydroxyphenylalanine (DOPA). A cyclic voltammetric study of the redox reaction revealed that the enantioselectivity was determined by the surface coverage of the gold electrode with Cys molecules. The electrode modified with ∼1.8 × 1014 Cys molecules cm-2 exhibited enantioselectivity in the voltammogram for the oxidation and reduction of DOPA, while the voltammograms obtained by the electrodes with either more or less surface coverages did not exhibit significant enantioselectivity. It is suggested that the accessibility of DOPA to that area of the gold surface which is not blocked by Cys molecules at an optimum surface coverage, is required for the enantioselective redox reaction of DOPA to proceed.

本文言語English
ページ(範囲)295-299
ページ数5
ジャーナルChirality
19
4
DOI
出版ステータスPublished - 2007 5月 2

ASJC Scopus subject areas

  • 分析化学
  • 触媒
  • 薬理学
  • 創薬
  • 分光学
  • 有機化学

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