Effect of the surfactant pluronic on the stability of lipid-stabilized perfluorocarbon nanobubbles

Lenitza Nieves, Christopher Hernandez, Jacob Lilly, Joey Mangadlao, Rigoberto Advincula, Agata Exner

    研究成果: Conference contribution

    1 被引用数 (Scopus)

    抄録

    Microbubble (MB) contrast agents are widely used in diagnostic and therapeutic ultrasound (US) applications. However, due to their 1-10 μm size range, MBs have limited use in cancer detection and treatment. To expand contrast enhanced US capabilities, we have developed sub-micron contrast agents, nanobubbles (NB), via the addition of Pluronic, a nonionic triblock copolymer surfactant, to the phospholipid shell stabilizing perfluoropropane (C3F8) gas (Fig 1A). NBs, with diameter of ∼200nm, can take advantage of the EPR effect, extravasate the leaky tumor vasculature and accumulate in tumors. Prior work has shown that bubble echogenicity and stability are, in part, dependent on the surface tension of the stabilizing shell. In this study, we evaluate the effect of Pluronic on surface tension of the lipid films and how its presence in the NB shell affects echogenicity and signal decay at clinically-relevant imaging frequencies.

    本文言語English
    ホスト出版物のタイトル2017 IEEE International Ultrasonics Symposium, IUS 2017
    出版社IEEE Computer Society
    ISBN(電子版)9781538633830
    DOI
    出版ステータスPublished - 2017 10月 31
    イベント2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
    継続期間: 2017 9月 62017 9月 9

    Other

    Other2017 IEEE International Ultrasonics Symposium, IUS 2017
    国/地域United States
    CityWashington
    Period17/9/617/9/9

    ASJC Scopus subject areas

    • 音響学および超音波学

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