Effect of vitamin E on learning and memory deficit in aged rats

Hirokatsu Takatsu, Kei Owada, Kouichi Abe, Masahiro Nakano, Shiro Urano*


研究成果: Article査読

48 被引用数 (Scopus)


In order to verify whether vitamin E improves the cognitive impairment induced through aging, aged rats fed a vitamin E-supplemented diet had their learning and memory functions assessed in comparison with the aged rats fed a normal diet using a Morris water maze test. Although normal aged rats showed very poor learning ability concerning the place of a platform in the water maze apparatus, the aged rats fed the vitamin E-supplemented diet learned the place with a marked speed in only 5 trials. After old animals showed the maximum learning ability, they were kept in a normal atmosphere for 48 h without a trial followed by an assessment of their memory function using the same apparatus. The vitamin E-supplementation to aged rats resulted in marked retention of their maximum memory function, although normal aged rats showed a significant memory loss of about 60%. Pyrroloquinoline quinone (PQQ), which increases in the production of nerve growth factor, and protects neurons, had a similar effect on cognitive function to that of vitamin E in the aged rats. These results suggest that vitamin E may improve cognitive deficit caused through aging by not only its neuro-protecting effect but an antioxidant efficacy.

ジャーナルJournal of Nutritional Science and Vitaminology
出版ステータスPublished - 2009

ASJC Scopus subject areas

  • 医学(その他)
  • 栄養および糖尿病


「Effect of vitamin E on learning and memory deficit in aged rats」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。