Effects and serum levels of thrombopoietin in a case of chronic thrombocytopenia with achondroplasia

Akira Ishiguro*, Tatsutoshi Nakahata, Kenji Muraoka, Tahara Tomoyuki Tahara, Hiroshi Miyazaki, Takashi Kato, Yuji Inaba, Toshikazu Shimbo

*この研究の対応する著者

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Thrombopoietin (TPO), produced mainly in the liver, is a major regulator of platelet production. Serum TPO levels are generally increased in thrombocytopenia. We report a case of a 12-year-old boy with chronic severe thrombocytopenia, achondroplasia and nephritis. Severe chronic thrombocytopenia was found at 9 months of age. It was resistant to any treatment. Studies on megakaryocytic colonies in vitro revealed that the marrow cells responded well to TPO and no plasma inhibitor was found. Although hepatic function test results were normal, serum TPO levels in the patient (0.94 fmol/ml) were consistent with those in age-matched children (0.49 1.75 fmol/ml). Chronic thrombocytopenia requires individual evaluation before clinical trials with TPO.

本文言語English
ページ(範囲)99-102
ページ数4
ジャーナルInternational Journal of Hematology
66
1
DOI
出版ステータスPublished - 1997 7月
外部発表はい

ASJC Scopus subject areas

  • 血液学

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