Effects of a single bout of aerobic exercise on short-term low-carbohydrate/high-fat intake-induced postprandial glucose metabolism during an oral glucose tolerance test

Shigeharu Numao, Hiroshi Kawano, Naoya Endo, Yuka Yamada, Masayuki Konishi, Masaki Takahashi, Shizuo Sakamoto

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Objective A single bout of exercise can improve acute postprandial glucose metabolism aggravated by short-term low-carbohydrate/high-fat diet (HFD). The purpose of this study was to investigate the effect of a single bout of aerobic exercise on short-term HFD-induced postprandial glucose and incretin metabolism during an oral glucose tolerance test (OGTT). Materials/Methods Eleven healthy young men (age [mean ± SE] 27 ± 1 years; body mass index, 22 ± 1 kg/m2) performed three, 3-day interventions in randomized order: (1) a normal diet (ND: ∼ 22% fat), (2) an HFD (∼ 69% fat) and (3) an HFD with a single bout of aerobic exercise (HFDEx). The exercise (50% peak oxygen consumption; ∼ 200 kcal) was performed on the third day in HFDEx. An OGTT was performed after each 3-day dietary intervention. Results The incremental area under the curve (iAUC) of plasma glucose levels during the OGTT was significantly higher in the HFD and HFDEx trials than in the ND trial (P = 0.001). In addition, the iAUC of glucagon-like peptide-1 (GLP-1) level was significantly higher in the HFD trial than in the ND and HFDEx trials (P = 0.04). The first-phase insulin secretion indexes were significantly lower in the HFD (P = 0.01 and 0.002) and HFDEx trials (P = 0.05 and 0.008) than in the ND trial. Conclusion A single bout of aerobic exercise did not improve the short-term HFD-induced aggravation of postprandial glucose and insulin metabolism during the OGTT. However, it did normalize the increased postprandial GLP-1 level induced by HFD.

本文言語English
ページ(範囲)1406-1415
ページ数10
ジャーナルMetabolism: Clinical and Experimental
62
10
DOI
出版ステータスPublished - 2013 10

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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