Effects of activin A on anterior pituitary cells fractionated by centrifugal elutriation

Tetsuro Katayama*, Kunio Shiota, Michio Takahashi

*この研究の対応する著者

研究成果: Article査読

7 被引用数 (Scopus)

抄録

We have shown previously that activin A increases the number of immunoreactive follicle-stimulating hormone (FSH) cells. To further investigate the action of activin A, we examined its effects on anterior pituitary cells fractionated by centrifugal elutriation. Before activin A treatment, FSH cells were widely distributed among various fractions; a higher proportion of FSH cells was found in larger cell fractions (fractions 5-9), and a lower proportion in smaller cell fractions (fractions 2-4). After culture of the cells in each fraction with activin A (10 ng/ml) for 72 h, the number of FSH cells in fraction 4 only was significantly (P<0.05) higher by 225% than that in cells cultured without activin A. The amount of FSH secreted into the medium was minimal or undetectable in fractions 1-4. However, FSH secretion tended to be, or was significantly (P

本文言語English
ページ(範囲)167-173
ページ数7
ジャーナルMolecular and Cellular Endocrinology
77
1-3
DOI
出版ステータスPublished - 1991
外部発表はい

ASJC Scopus subject areas

  • 内分泌学
  • 内分泌学、糖尿病および代謝内科学

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