Effects of bovine colostrum supplementation on immune variables in highly trained cyclists

Cecilia M. Shing, Jonathan Peake, Katsuhiko Suzuki, Mitsuharu Okutsu, Rosie Pereira, Lesley Stevenson, David G. Jenkins, Jeff S. Coombes

研究成果: Article査読

57 被引用数 (Scopus)

抄録

The aim of this study was to investigate the influence of low-dose bovine colostrum protein concentrate (CPC) supplementation on selected immune variables in cyclists. Twenty-nine highly trained male road cyclists completed an initial 40-km time trial (TT40) and were then randomly assigned to either a supplement (n = 14, 10 g bovine CPC/day) or placebo group (n = 15, 10 g whey protein concentrate/day). After 5 wk of supplementation, the cyclists completed a second TT40. They then completed 5 consecutive days of high-intensity training (HIT) that included a TT40, followed by a final TT40 in the following week. Venous blood and saliva samples were collected immediately before and after each TT40, and upper respiratory illness symptoms were recorded over the experimental period. Compared with the placebo group, bovine CPC supplementation significantly increased preexercise serum soluble TNF receptor 1 during the HIT period (bovine CPC = 882 ± 233 pg/ml, placebo = 468 ± 139 pg/ml; P = 0.039). Supplementation also suppressed the postexercise decrease in cytotoxic/suppressor T cells during the HIT period (bovine CPC = -1.0 ± 2.7%, placebo = -9.2 ± 2.8%; P = 0.017) and during the following week (bovine CPC = 1.4 ± 2.9%, placebo = -8.2 ± 2.8%; P = 0.004). Bovine CPC supplementation prevented a postexercise decrease in serum IgG 2 concentration at the end of the HIT period (bovine CPC = 4.8 ± 6.8%, P = 0.88; placebo = -9.7 ± 6.9%, P = 0.013). There was a trend toward reduced incidence of upper respiratory illness symptoms in the bovine CPC group (P = 0.055). In summary, low-dose bovine CPC supplementation modulates immune parameters during normal training and after an acute period of intense exercise, which may have contributed to the trend toward reduced upper respiratory illness in the bovine CPC group.

本文言語English
ページ(範囲)1113-1122
ページ数10
ジャーナルJournal of Applied Physiology
102
3
DOI
出版ステータスPublished - 2007 3

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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