抄録
The role of calcium ions in maintenance of the circadian rhythm in glucose utilization in the suprachiasmatic nucleus (SCN) of the hypothalamus was investigated in vitro in a rat hypothalamic slice preparation using the 2-deoxyglucose (2-DG) method. In normal Krebs solution, 2-DG uptake of adult and embryonic day 22 rat SCN was higher in subjective day than in subjective night. In calcium-free Krebs solution, however, 2-DG uptake of adult and embryonic SCN was low in both subjective day and night periods. These results indicate that the SCN rhythm in metabolic activity is dependent on calcium ions in both adult and embryonic rats. Since immunohistochemical and ultrastructural analysis of synapse formation has shown very few synapses in the SCN of embryonic day 22 rats, it is suggested that the development and maintenance of the circadian rhythm in metabolism demonstrated by the 2-DG method depends on intracellular calcium-mediated events rather than synaptic transmission.
本文言語 | English |
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ページ(範囲) | 332-338 |
ページ数 | 7 |
ジャーナル | Brain Research |
巻 | 426 |
号 | 2 |
DOI | |
出版ステータス | Published - 1987 11月 24 |
外部発表 | はい |
ASJC Scopus subject areas
- 神経科学(全般)
- 分子生物学
- 臨床神経学
- 発生生物学