Effects of chronic administration of antidepressants on mouse-killing behavior (muricide) in olfactory bulbectomized rats

Shigenobu Shibata*, Hiroshi Nakanishi, Shigenori Watanabe, Showa Ueki

*この研究の対応する著者

研究成果: Article査読

41 被引用数 (Scopus)

抄録

Two forms of drug administration, i.e., systemic subcutaneous administration and microinjection into the medial amygdala were employed to examine the effect of chronic administration of psychotropic drug on muricide in olfactory bulbectomized rats. Muricide inhibition induced by the systemic doses of chlorpromazine (CPZ) 10 mg/kg and diazepam 10 mg/kg was reduced with chronic administration, while that by desipramine (DMI) 10 mg/kg and amitriptyline 30 mg/kg was augmented with chronic adminstration. Muricide inhibition induced by microinjection of CPZ was also reduced, while that by DMI was augmented. These results indicate that muricide by olfactory bulbectomized rats is a useful animal model for evaluating antidepressants and that a potential site of action of antidepressants is located in the medial amygdala.

本文言語English
ページ(範囲)225-230
ページ数6
ジャーナルPharmacology, Biochemistry and Behavior
21
2
DOI
出版ステータスPublished - 1984 8月
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 毒物学
  • 薬理学
  • 臨床生化学
  • 生物学的精神医学
  • 行動神経科学

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