抄録
In order to elucidate the role of cyclic nucleotides in the suprachiasmatic nucleus, we examined the effect of dibutyryl cyclic AMP (c-AMP) and dibutyryl cyclic GMP (c-GMP) on single neuronal activity of the suprachiasmatic nucleus of the rat. A hypothalamic slice about 300 μm thick, including the suprachiasmatic nucleus, was cut coronally using a vibratome. By means of bath- as well as iontophoretic application, c-AMP and c-GMP caused mainly an inhibition and facilitation in suprachiasmatic neuronal activity, respectively. The present results suggest that c-AMP and c-GMP play an important role in regulation of suprachiasmatic neuronal activity as a second messenger and that these two nucleotides may function as a reciprocal messenger.
本文言語 | English |
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ページ(範囲) | 339-343 |
ページ数 | 5 |
ジャーナル | Neuroscience Letters |
巻 | 67 |
号 | 3 |
DOI | |
出版ステータス | Published - 1986 6 30 |
外部発表 | はい |
ASJC Scopus subject areas
- Neuroscience(all)