抄録
In order to elucidate the role of cyclic nucleotides in the suprachiasmatic nucleus, we examined the effect of dibutyryl cyclic AMP (c-AMP) and dibutyryl cyclic GMP (c-GMP) on single neuronal activity of the suprachiasmatic nucleus of the rat. A hypothalamic slice about 300 μm thick, including the suprachiasmatic nucleus, was cut coronally using a vibratome. By means of bath- as well as iontophoretic application, c-AMP and c-GMP caused mainly an inhibition and facilitation in suprachiasmatic neuronal activity, respectively. The present results suggest that c-AMP and c-GMP play an important role in regulation of suprachiasmatic neuronal activity as a second messenger and that these two nucleotides may function as a reciprocal messenger.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 339-343 |
| ページ数 | 5 |
| ジャーナル | Neuroscience Letters |
| 巻 | 67 |
| 発行部数 | 3 |
| DOI | |
| 出版物ステータス | Published - 1986 6 30 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
これを引用
Effects of dibutyryl cyclic adenosine monophosphate and dibutyryl cyclic guanosine monophosphate on neuron activity of suprachiasmatic nucleus in rat hypothalamic slice preparation. / Liou, Shyh Yuh; Shibata, Shigenobu; Shiratsuchi, Akiko; Ueki, Showa.
：: Neuroscience Letters, 巻 67, 番号 3, 30.06.1986, p. 339-343.研究成果: Article
}
TY - JOUR
T1 - Effects of dibutyryl cyclic adenosine monophosphate and dibutyryl cyclic guanosine monophosphate on neuron activity of suprachiasmatic nucleus in rat hypothalamic slice preparation
AU - Liou, Shyh Yuh
AU - Shibata, Shigenobu
AU - Shiratsuchi, Akiko
AU - Ueki, Showa
PY - 1986/6/30
Y1 - 1986/6/30
N2 - In order to elucidate the role of cyclic nucleotides in the suprachiasmatic nucleus, we examined the effect of dibutyryl cyclic AMP (c-AMP) and dibutyryl cyclic GMP (c-GMP) on single neuronal activity of the suprachiasmatic nucleus of the rat. A hypothalamic slice about 300 μm thick, including the suprachiasmatic nucleus, was cut coronally using a vibratome. By means of bath- as well as iontophoretic application, c-AMP and c-GMP caused mainly an inhibition and facilitation in suprachiasmatic neuronal activity, respectively. The present results suggest that c-AMP and c-GMP play an important role in regulation of suprachiasmatic neuronal activity as a second messenger and that these two nucleotides may function as a reciprocal messenger.
AB - In order to elucidate the role of cyclic nucleotides in the suprachiasmatic nucleus, we examined the effect of dibutyryl cyclic AMP (c-AMP) and dibutyryl cyclic GMP (c-GMP) on single neuronal activity of the suprachiasmatic nucleus of the rat. A hypothalamic slice about 300 μm thick, including the suprachiasmatic nucleus, was cut coronally using a vibratome. By means of bath- as well as iontophoretic application, c-AMP and c-GMP caused mainly an inhibition and facilitation in suprachiasmatic neuronal activity, respectively. The present results suggest that c-AMP and c-GMP play an important role in regulation of suprachiasmatic neuronal activity as a second messenger and that these two nucleotides may function as a reciprocal messenger.
KW - cyclic nucleotide
KW - electrophysiology
KW - rat
KW - single neuron
KW - suprachiasmatic nucleus
UR - http://www.scopus.com/inward/record.url?scp=0022552441&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022552441&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(86)90333-2
DO - 10.1016/0304-3940(86)90333-2
M3 - Article
C2 - 3016614
AN - SCOPUS:0022552441
VL - 67
SP - 339
EP - 343
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -