Effects of folic acid supplementation on inflammatory markers: A grade-assessed systematic review and dose–response meta-analysis of randomized controlled trials

Omid Asbaghi, Damoon Ashtary-Larky, Reza Bagheri, Parisa Moosavian, Behzad Nazarian, Reza Afrisham, Mahnaz Rezaei Kelishadi, Alexei Wong, Frédéric Dutheil, Katsuhiko Suzuki*, Amirmansour Alavi Naeini

*この研究の対応する著者

研究成果: Article査読

抄録

BackgroundIt has been theorized that folic acid supplementation improves inflammation. However, its proven effects on inflammatory markers are unclear as clinical studies on this topic have produced inconsistent results. To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Methods: To identify eligible RCTs, a systematic search up to April 2021 was completed in PubMed/Medline, Scopus, Web of Science, EMBASE, Cochrane databases, and Google Scholar using relevant keywords. A fix or random-effects model was utilized to estimate the weighted mean difference (WMD) and 95% confidence interval (95% CI). Results: Twelve RCTs were included in the present meta-analysis. The pooled analysis revealed that serum concentrations of CRP (WMD: −0.59 mg/L, 95% CI −0.85 to −0.33, p < 0.001) were significantly reduced following folic acid supplementation compared to placebo, but did not affect serum concentrations of IL-6 (WMD: −0.12, 95% CI −0.95 to 0.72 pg/mL, p = 0.780) or TNF-α (WMD: −0.18, 95% CI −0.86 to 0.49 pg/mL, p = 0.594). The dose–response analysis demonstrated a significant relationship between an elevated dosage of folic acid supplementation and lower CRP concentrations (p = 0.002). Conclusions: We found that folic acid supplementation may improve inflammation by attenuating serum concentrations of CRP but without significant effects on IL-6 and TNF-α. Future RCTs including a larger number of participants and more diverse populations are needed to confirm and expand our findings.

本文言語English
論文番号2327
ジャーナルNutrients
13
7
DOI
出版ステータスPublished - 2021 7

ASJC Scopus subject areas

  • 食品科学
  • 栄養および糖尿病

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