Effects of lycopene on spontaneous mammary tumour development in SHN virgin mice

H. Nagasawa*, T. Mitamura, S. Sakamoto, K. Yamamoto

*この研究の対応する著者

研究成果: Article査読

134 被引用数 (Scopus)

抄録

Effects of the chronic ingestion of lycopene, a caroteniod from tomato, on the development of spontaneous mammary tumours were examined in a high mammary tumor strain of SHN virgin mice. Beginning at 40 days of age, the control and the experimental groups were allowed free access to an AIN-76TM diet and diet supplemented further with lycopene at the concentration of 5.0 x 10-5%, respectively. The treatment significantly suppressed the mammary tumor development, which suppression was associated with the decrease in the mammary gland activity of thymidylate synthetase, and serum levels of free fatty acid an prolactin. Body weight was little affected and no deleterious side-effects of lycopene were detected. All results show that lycopene could be promising as a chemopreventive agent for mammary and other types of tumors.

本文言語English
ページ(範囲)1173-1178
ページ数6
ジャーナルAnticancer Research
15
4
出版ステータスPublished - 1995
外部発表はい

ASJC Scopus subject areas

  • 癌研究
  • 腫瘍学

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