Effects of melatonin on neuronal activity in the rat suprachiasmatic nucleus in vitro

Shigenobu Shibata, Vincent M. Cassone, Robert Y. Moore

研究成果: Article

135 引用 (Scopus)

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The pineal hormone melatonin is believed to act directly on the hypothalamic suprachiasmatic nuclei (SCN), which are principal circadian pacemakers in rodents, although direct demonstration of this is lacking. To determine whether the SCN are sensitive to melatonin electrophysiologically, we investigated the effect of melatonin on rat SCN single-unit activity in an in vitro hypothalamic slice preparation. SCN single-unit activity was inhibited by melatonin superfusion during the late subjective day in a dose-dependent manner but not at other times of day, supporting the view that melatonin acts directly on SCN neurons.

元の言語English
ページ(範囲)140-144
ページ数5
ジャーナルNeuroscience Letters
97
発行部数1-2
DOI
出版物ステータスPublished - 1989 2 13

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ASJC Scopus subject areas

  • Neuroscience(all)

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