Effects of melatonin on neuronal activity in the rat suprachiasmatic nucleus in vitro

Shigenobu Shibata*, Vincent M. Cassone, Robert Y. Moore

*この研究の対応する著者

研究成果: Article査読

136 被引用数 (Scopus)

抄録

The pineal hormone melatonin is believed to act directly on the hypothalamic suprachiasmatic nuclei (SCN), which are principal circadian pacemakers in rodents, although direct demonstration of this is lacking. To determine whether the SCN are sensitive to melatonin electrophysiologically, we investigated the effect of melatonin on rat SCN single-unit activity in an in vitro hypothalamic slice preparation. SCN single-unit activity was inhibited by melatonin superfusion during the late subjective day in a dose-dependent manner but not at other times of day, supporting the view that melatonin acts directly on SCN neurons.

本文言語English
ページ(範囲)140-144
ページ数5
ジャーナルNeuroscience Letters
97
1-2
DOI
出版ステータスPublished - 1989 2月 13
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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