Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation

Yoko Tanabe, Kentaro Chino, Takahiro Ohnishi, Hitomi Ozawa, Hiroyuki Sagayama, Seiji Maeda, Hideyuki Takahashi*

*この研究の対応する著者

研究成果: Article査読

17 被引用数 (Scopus)

抄録

We examined the effect of curcumin (CUR) ingestion before or after exercise on changes in muscle damage and inflammatory responses after exercise. We conducted two parallel experiments with different CUR ingestion timings using a double-blind crossover. In Exp. 1, ten healthy men ingested 180 mg d −1 of CUR or placebo (PLA) 7 days before exercise. In Exp. 2, ten other healthy men ingested 180 mg d −1 of CUR or PLA 7 days after exercise. They performed 30 maximal isokinetic (120°s −1 ) eccentric contractions of the elbow flexors using an isokinetic dynamometer, and this was repeated with the other arm ≥4 weeks later. Maximal voluntary contraction (MVC) torque of the elbow flexors, elbow joint range of motion (ROM), muscle soreness, and serum creatine kinase (CK) activity were measured before, immediately after, and 1-7 days after exercise. Plasma interleukin-8 (IL-8) was measured before, immediately after, 12 hours after, and 1-7 days after exercise. The changes were compared over time. In Exp. 1, no significant differences were found between CUR and PLA subjects for each parameter. However, increases in IL-8 were significantly reduced 12 hours after exercise when CUR was ingested before exercise. In Exp. 2, compared to the PLA subjects, MVC torque and ROM were higher 3-7 days and 2-7 days after exercise (P < 0.05), respectively, whereas muscle soreness and CK activity were lower 3-6 days and 5-7 days after exercise (P < 0.05), respectively, in CUR subjects. CUR ingestion before exercise could attenuate acute inflammation, and after exercise could attenuate muscle damage and facilitate faster recovery.

本文言語English
ページ(範囲)524-534
ページ数11
ジャーナルScandinavian Journal of Medicine and Science in Sports
29
4
DOI
出版ステータスPublished - 2019 4
外部発表はい

ASJC Scopus subject areas

  • 整形外科およびスポーツ医学
  • 理学療法、スポーツ療法とリハビリテーション

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