Effects of temperature and concentration in some ring closing metathesis reactions

Kana Yamamoto, Kaustav Biswas, Christoph Gaul, Samuel J. Danishefsky

研究成果: Article

64 引用 (Scopus)

抜粋

Ring closing metathesis (RCM) has emerged as a powerful tool to construct macrocyclic ring systems. However, the product distribution of monomer and oligomers is often a problem in the formation of medium to large rings. In the course of synthetic studies on the natural product radicicol and its analogs, we have found that the reaction temperature, along with concentration, has significant impact on the outcome of the product ratio. Specifically, carrying out the RCM reaction in refluxing toluene (110°C) at higher dilution affords improved yields of the monomeric macrocycle. Similar observations for another family of macrolactone natural products, the epothilones, are also reported.

元の言語English
ページ(範囲)3297-3299
ページ数3
ジャーナルTetrahedron Letters
44
発行部数16
DOI
出版物ステータスPublished - 2003 4 14

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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