Effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in healthy men

Masaki Takahashi, Mamiho Ozaki, Masashi Miyashita, Mayuko Fukazawa, Takashi Nakaoka, Takuya Wakisaka, Yuji Matsui, Masanobu Hibi, Noriko Osaki, Shigenobu Shibata

研究成果: Article

抄録

Green tea polyphenols, particularly catechins, decrease fasting and postprandial glucose. However, no studies have compared the timing of green tea ingestion on glucose metabolism and changes in catechin concentrations. Here, we examined the effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in young men. Seventeen healthy young men completed four trials involving blood collection in a fasting state and at 30, 60, 120, and 180 min after meal consumption in a random order: 1) morning placebo trial (09:00 h; MP trial), 2) evening placebo trial (17:00 h; EP trial), 3) morning catechin-rich green tea trial (09:00 h; MGT trial), and 4) evening catechin-rich green tea trial (17:00 h; EGT trial). The concentrations of glucose at 120 min (P=.031) and 180 min (P=.013) after meal intake were significantly higher in the MGT trials than in the MP trials. Additionally, the concentration of glucose was significantly lower in EGT trials than in the EP trials at 60 min (P=.014). Moreover, the concentrations of glucose-dependent insulinotropic polypeptide were significantly lower in the green tea trials than in the placebo trials at 30 min (morning: P=.010, evening: P=.006) and 60 min (morning: P=.001, evening: P=.006) after meal intake in both the morning and evening trials. Our study demonstrated that acute ingestion of catechin-rich green tea in the evening reduced postprandial plasma glucose concentrations.

元の言語English
記事番号108221
ジャーナルJournal of Nutritional Biochemistry
73
DOI
出版物ステータスPublished - 2019 11 1

Fingerprint

Catechin
Tea
Metabolism
Eating
Glucose
Meals
Placebos
Fasting
Polyphenols
Blood
Plasmas
Peptides

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry

これを引用

Effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in healthy men. / Takahashi, Masaki; Ozaki, Mamiho; Miyashita, Masashi; Fukazawa, Mayuko; Nakaoka, Takashi; Wakisaka, Takuya; Matsui, Yuji; Hibi, Masanobu; Osaki, Noriko; Shibata, Shigenobu.

:: Journal of Nutritional Biochemistry, 巻 73, 108221, 01.11.2019.

研究成果: Article

Takahashi, Masaki ; Ozaki, Mamiho ; Miyashita, Masashi ; Fukazawa, Mayuko ; Nakaoka, Takashi ; Wakisaka, Takuya ; Matsui, Yuji ; Hibi, Masanobu ; Osaki, Noriko ; Shibata, Shigenobu. / Effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in healthy men. :: Journal of Nutritional Biochemistry. 2019 ; 巻 73.
@article{4e93fbe79dfe4043835ed4629a4eee2c,
title = "Effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in healthy men",
abstract = "Green tea polyphenols, particularly catechins, decrease fasting and postprandial glucose. However, no studies have compared the timing of green tea ingestion on glucose metabolism and changes in catechin concentrations. Here, we examined the effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in young men. Seventeen healthy young men completed four trials involving blood collection in a fasting state and at 30, 60, 120, and 180 min after meal consumption in a random order: 1) morning placebo trial (09:00 h; MP trial), 2) evening placebo trial (17:00 h; EP trial), 3) morning catechin-rich green tea trial (09:00 h; MGT trial), and 4) evening catechin-rich green tea trial (17:00 h; EGT trial). The concentrations of glucose at 120 min (P=.031) and 180 min (P=.013) after meal intake were significantly higher in the MGT trials than in the MP trials. Additionally, the concentration of glucose was significantly lower in EGT trials than in the EP trials at 60 min (P=.014). Moreover, the concentrations of glucose-dependent insulinotropic polypeptide were significantly lower in the green tea trials than in the placebo trials at 30 min (morning: P=.010, evening: P=.006) and 60 min (morning: P=.001, evening: P=.006) after meal intake in both the morning and evening trials. Our study demonstrated that acute ingestion of catechin-rich green tea in the evening reduced postprandial plasma glucose concentrations.",
keywords = "Circadian rhythm, Epigallocatechin gallate, Glucose metabolism, Incretin, Meal timing",
author = "Masaki Takahashi and Mamiho Ozaki and Masashi Miyashita and Mayuko Fukazawa and Takashi Nakaoka and Takuya Wakisaka and Yuji Matsui and Masanobu Hibi and Noriko Osaki and Shigenobu Shibata",
year = "2019",
month = "11",
day = "1",
doi = "10.1016/j.jnutbio.2019.108221",
language = "English",
volume = "73",
journal = "Journal of Nutritional Biochemistry",
issn = "0955-2863",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in healthy men

AU - Takahashi, Masaki

AU - Ozaki, Mamiho

AU - Miyashita, Masashi

AU - Fukazawa, Mayuko

AU - Nakaoka, Takashi

AU - Wakisaka, Takuya

AU - Matsui, Yuji

AU - Hibi, Masanobu

AU - Osaki, Noriko

AU - Shibata, Shigenobu

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Green tea polyphenols, particularly catechins, decrease fasting and postprandial glucose. However, no studies have compared the timing of green tea ingestion on glucose metabolism and changes in catechin concentrations. Here, we examined the effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in young men. Seventeen healthy young men completed four trials involving blood collection in a fasting state and at 30, 60, 120, and 180 min after meal consumption in a random order: 1) morning placebo trial (09:00 h; MP trial), 2) evening placebo trial (17:00 h; EP trial), 3) morning catechin-rich green tea trial (09:00 h; MGT trial), and 4) evening catechin-rich green tea trial (17:00 h; EGT trial). The concentrations of glucose at 120 min (P=.031) and 180 min (P=.013) after meal intake were significantly higher in the MGT trials than in the MP trials. Additionally, the concentration of glucose was significantly lower in EGT trials than in the EP trials at 60 min (P=.014). Moreover, the concentrations of glucose-dependent insulinotropic polypeptide were significantly lower in the green tea trials than in the placebo trials at 30 min (morning: P=.010, evening: P=.006) and 60 min (morning: P=.001, evening: P=.006) after meal intake in both the morning and evening trials. Our study demonstrated that acute ingestion of catechin-rich green tea in the evening reduced postprandial plasma glucose concentrations.

AB - Green tea polyphenols, particularly catechins, decrease fasting and postprandial glucose. However, no studies have compared the timing of green tea ingestion on glucose metabolism and changes in catechin concentrations. Here, we examined the effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in young men. Seventeen healthy young men completed four trials involving blood collection in a fasting state and at 30, 60, 120, and 180 min after meal consumption in a random order: 1) morning placebo trial (09:00 h; MP trial), 2) evening placebo trial (17:00 h; EP trial), 3) morning catechin-rich green tea trial (09:00 h; MGT trial), and 4) evening catechin-rich green tea trial (17:00 h; EGT trial). The concentrations of glucose at 120 min (P=.031) and 180 min (P=.013) after meal intake were significantly higher in the MGT trials than in the MP trials. Additionally, the concentration of glucose was significantly lower in EGT trials than in the EP trials at 60 min (P=.014). Moreover, the concentrations of glucose-dependent insulinotropic polypeptide were significantly lower in the green tea trials than in the placebo trials at 30 min (morning: P=.010, evening: P=.006) and 60 min (morning: P=.001, evening: P=.006) after meal intake in both the morning and evening trials. Our study demonstrated that acute ingestion of catechin-rich green tea in the evening reduced postprandial plasma glucose concentrations.

KW - Circadian rhythm

KW - Epigallocatechin gallate

KW - Glucose metabolism

KW - Incretin

KW - Meal timing

UR - http://www.scopus.com/inward/record.url?scp=85072207382&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072207382&partnerID=8YFLogxK

U2 - 10.1016/j.jnutbio.2019.108221

DO - 10.1016/j.jnutbio.2019.108221

M3 - Article

C2 - 31522082

AN - SCOPUS:85072207382

VL - 73

JO - Journal of Nutritional Biochemistry

JF - Journal of Nutritional Biochemistry

SN - 0955-2863

M1 - 108221

ER -