Efficacy and safety of mirtazapine in university students with depression: A comparison with elderly patients

Terumi Ishii*, Takafumi Hori, Hirokazu Tachikawa, Kimitaka Hatanaka, Takashi Asada

*この研究の対応する著者

研究成果: Article査読

抄録

When clinicians are concerned about an increased risk of suicidality induced by antidepressants in young patients, mirtazapine is considered a suitable option because of its low risk of provoking suicidality and its sedative effect. However, mirtazapine often needs to be discontinued or the dose reduced because of drowsiness, especially in young persons. This study retrospectively compared the clinical effects of mirtazapine in 16 young university students to those in 16 elderly patients with depression. Drowsiness was the most frequent side effect, and was observed more often in the students. Greater numbers of students also had their doses reduced or stopped using mirtazapine specifically because of oversedation. Furthermore, the final dose of mirtazapine was much lower in the student group even though the therapeutic effects were similar to those in the elderly group, suggesting that lower doses of mirtazapine should be administered to young depressed patients as starting or maintenance doses to avoid sedation and achieve a minimal level of therapeutic efficacy.

本文言語English
ページ(範囲)1-4
ページ数4
ジャーナルClinical Neuropsychopharmacology and Therapeutics
6
DOI
出版ステータスPublished - 2015 1 16
外部発表はい

ASJC Scopus subject areas

  • 臨床神経学
  • 精神医学および精神衛生
  • 薬理学(医学)

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