Background: Reduction in recovery time may prevent physiological variables from returning to pre exercise levels; therefore, it is likely that the athletes will have a decrease in immune response and experience increased stress. The purpose of the current study was to examine whether two consecutive or non-consecutive days of circuit resistance exercise (CRE) on cortisol, creatine kinase (CK) and immunoglobulin A (IgA) responses in active young men. Methods: Ten healthy male university students (22.25 ± 1.61 years) performed two consecutive days of circuit resistance exercise (TCD-CRE) and two non-consecutive days of circuit resistance exercise (TNCD-CRE). Participants performed CRE at 75% of their one-repetition maximum (1RM). Blood and saliva samples were taken during baseline and immediately after exercise and analyzed for serum CK activity and salivary concentrations of cortisol and IgA. Results: Based on the results, there were significant increases in cortisol and CK at post as compared with pre in the TCD-CRE group (P ˂ 0.001, P = 0.001). Also, a significant increase in cortisol at post as compared with pre in the TNCD-CRE group was observed (P ˂ 0.001). Additionally, the level of IgA was significantly reduced post exercise when compared to pre value in the TCD-CRE group (P = 0.011). On the contrary, there were no significant changes in concentrations of IgA and CK activity in the TNCD-CRE group (P = 0.11, P = 0.24). Moreover, there were statistically significant differences in cortisol and CK between the groups (P = 0.001, P = 0.002). Conclusion: Based on these data, TCD-CRE causes more immunological responses, and thus may lead to trauma. It seems that there is a need for a 48-h recovery between exercise sessions to prevent the decrease in immune function by CRE.
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