Elastic origin of chiral selection in DNA wrapping

Tomohiro Yanao*, Kenichi Yoshikawa

*この研究の対応する著者

研究成果: Article査読

9 被引用数 (Scopus)

抄録

We investigated the mechanism that underlies the chiral selection on the direction of wrapping of DNA around a nucleosome core particle. A coarse-grained model for the formation of a nucleosome is introduced, in which DNA is treated as a semiflexible polymer and the histone core is modeled by a spherical particle. Asymmetric coupling between bending and twisting is incorporated into the model DNA, which is expected from the double-stranded helical structure of DNA. We show that the tendency of DNA to twist in a left-handed manner upon bending gives rise to the selective left-handed wrapping, provided that the size of the core particle is chosen appropriately. This result suggests the critical importance of the chiral asymmetry inherent in the bending-twisting elasticity of DNA as well as the size of the core in determining the handedness of wrapping in nucleosome formation.

本文言語English
論文番号021904
ジャーナルPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
77
2
DOI
出版ステータスPublished - 2008 2 6
外部発表はい

ASJC Scopus subject areas

  • 統計物理学および非線形物理学
  • 統計学および確率
  • 凝縮系物理学

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