TY - JOUR
T1 - Electrochemical molecular sieving of the polyion complex film for designing highly sensitive biosensor for creatinine
AU - Osaka, Tetsuya
AU - Komaba, Shinichi
AU - Amano, Akio
AU - Fujino, Yusuke
AU - Mori, Hiroshi
PY - 2000/6/30
Y1 - 2000/6/30
N2 - On the basis of our success on creatinine sensor composed of immobilization of creatinine iminohydrolase by polyion complexes (PIC) with a combination of interfacial pH change detection by using inactive polypyrrole film, we investigated various combination of PIC and their sensitivities. The sensitivity of the creatinine sensor was dependent strongly on the distance of the functional units of the anionic species of PIC. The dependence of sensitivity was related to the molecular sieving of the PIC used for the immobilization of the enzyme, i.e., the diffusion of the analytes in the PIC.
AB - On the basis of our success on creatinine sensor composed of immobilization of creatinine iminohydrolase by polyion complexes (PIC) with a combination of interfacial pH change detection by using inactive polypyrrole film, we investigated various combination of PIC and their sensitivities. The sensitivity of the creatinine sensor was dependent strongly on the distance of the functional units of the anionic species of PIC. The dependence of sensitivity was related to the molecular sieving of the PIC used for the immobilization of the enzyme, i.e., the diffusion of the analytes in the PIC.
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U2 - 10.1016/S0925-4005(99)00423-2
DO - 10.1016/S0925-4005(99)00423-2
M3 - Conference article
AN - SCOPUS:0034733297
VL - 65
SP - 58
EP - 63
JO - Sensors and Actuators B: Chemical
JF - Sensors and Actuators B: Chemical
SN - 0925-4005
IS - 1
T2 - IMCS-7: 7th International Meeting on Chemical Sensors
Y2 - 27 July 1998 through 30 July 1998
ER -