Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin

Zahra Hemmatian, Scott Keene, Erik Josberger, Takeo Miyake, Carina Arboleda, Jessica Soto-Rodríguez, François Baneyx, Marco Rolandi

研究成果: Article

24 引用 (Scopus)

抜粋

In biological systems, intercellular communication is mediated by membrane proteins and ion channels that regulate traffic of ions and small molecules across cell membranes. A bioelectronic device with ion channels that control ionic flow across a supported lipid bilayer (SLB) should therefore be ideal for interfacing with biological systems. Here, we demonstrate a biotic-abiotic bioprotonic device with Pd contacts that regulates proton (H+) flow across an SLB incorporating the ion channels Gramicidin A (gA) and Alamethicin (ALM). We model the device characteristics using the Goldman-Hodgkin-Katz (GHK) solution to the Nernst-Planck equation for transport across the membrane. We derive the permeability for an SLB integrating gA and ALM and demonstrate pH control as a function of applied voltage and membrane permeability. This work opens the door to integrating more complex H+ channels at the Pd contact interface to produce responsive biotic-abiotic devices with increased functionality.

元の言語English
記事番号12981
ジャーナルNature Communications
7
DOI
出版物ステータスPublished - 2016 10 7
外部発表Yes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

フィンガープリント Electronic control of H<sup>+</sup> current in a bioprotonic device with Gramicidin A and Alamethicin' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Hemmatian, Z., Keene, S., Josberger, E., Miyake, T., Arboleda, C., Soto-Rodríguez, J., Baneyx, F., & Rolandi, M. (2016). Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin. Nature Communications, 7, [12981]. https://doi.org/10.1038/ncomms12981