Electropolymerized molecularly imprinted polymer films of a bis-terthiophene dendron: Folic acid quartz crystalmicrobalance sensing

Dahlia C. Apodaca, Roderick B. Pernites, Ramakrishna R. Ponnapati, Florian R. Del Mundo, Rigoberto C. Advincula*

*この研究の対応する著者

研究成果: Article査読

64 被引用数 (Scopus)

抄録

A folic acid sensor was prepared via an electropolymerized molecularly imprinted polymer (E-MIP) film of a bis-terthiophene dendron on a quartz crystal microbalance (QCM). The cyclic voltammetry (CV) electrodeposition of the imprinted polymer film was monitored by electrochemical QCM or E-QCM, enabling in situ monitoring and characterization of E-MIP film formation and the viscoelastic behavior of the film. A key component of the E-MIP process is the use of a bifunctional monomer design to precomplex with the template and function as a cross-linker. The complex was electropolymerized and cross-linked by CV to form a polythiophene matrix. Stable cavities were formed that specifically fit the size and shape of the folic acid template. The same substrate surface was used for folic acid sensing. The predicted geometry of the 1:2 folic acid/terthiophene complex was obtained through semiempirical AM1 quantum calculations. The analytical performance, expressed through the figures of merit, of the sensor in aqueous solutions of the analyte was investigated. A relatively good linearity, R 2 = 0.985, was obtained within the concentration range 0-100 μM folic acid. The detection limit was found to be equal to 15.4 μM (6.8 μg). The relative cross selectivity of the folic acid imprinted polymer against the three molecules follows this trend: pteroic acid (= 50%) > caffeine (= 41%) > theophylline (= 6%). The potential and limitations of the E-MIP method were also discussed.

本文言語English
ページ(範囲)191-203
ページ数13
ジャーナルACS Applied Materials and Interfaces
3
2
DOI
出版ステータスPublished - 2011 2月 23
外部発表はい

ASJC Scopus subject areas

  • 材料科学(全般)

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