Embryogenic remodeling of global chromatin and its role on structure of corresponding lattice representation

Yukio Pegio Gunji*, Igor Balaz

*この研究の対応する著者

研究成果査読

抄録

Recent findings demonstrate that chromatin is functionally compartmentalized and packed into three dimensional multi-hierarchical structures that influence gene expression patterns. Using lattice theory tools we compare lattice representation of unstructured DNA, as identified in early-embryo phase, with compartmentalized DNA, as found in later embryo phases and in differentiated cells. By comparing these two representations we show that corresponding contact maps have elementary diagonal structure (unstructured DNA) and block diagonal structure (compartmentalized DNA). We show that a lattice corresponding to the binary relation with block diagonal structure is a product of so called Chinese lantern lattice. In contrast to Boolean lattice, formation of words in Chinese lantern lattice is highly restricted which is comparable to emergence of DNA compartmentalization during embryogenesis.

本文言語English
ページ(範囲)273-280
ページ数8
ジャーナルBioSystems
173
DOI
出版ステータスPublished - 2018 11

ASJC Scopus subject areas

  • 統計学および確率
  • モデリングとシミュレーション
  • 生化学、遺伝学、分子生物学(全般)
  • 応用数学

フィンガープリント

「Embryogenic remodeling of global chromatin and its role on structure of corresponding lattice representation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル