Enantioselective Cross-Coupling of Electron-Deficient Alkenes via Ir-Catalyzed Vinylic sp2C-H Alkylation

Takanori Shibata; Masafumi Kojima; Sahoko Onoda; Mamoru Ito

doi:10.1021/acs.orglett.1c02823

Enantioselective Cross-Coupling of Electron-Deficient Alkenes via Ir-Catalyzed Vinylic sp²C-H Alkylation

Takanori Shibata^*, Masafumi Kojima, Sahoko Onoda, Mamoru Ito

^*この研究の対応する著者

先進理工学部

研究成果: Article › 査読

8 被引用数 (Scopus)

抄録

A chiral Ir-catalyzed reaction of α-aryl-α,β-unsaturated amides with β-substituted acrylates proceeded to give formal conjugate adducts in high yield and ee (up to 99% yield and up to 95% ee). This is the first example of the enantioselective cross-coupling of two different electron-deficient alkenes via vinylic sp2 C-H activation, and polyfunctionalized chiral compounds were obtained.

本文言語	English
ページ（範囲）	8158-8162
ページ数	5
ジャーナル	Organic Letters
巻	23
号	21
DOI	https://doi.org/10.1021/acs.orglett.1c02823
出版ステータス	Published - 2021 11月 5

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

文献へのアクセス

10.1021/acs.orglett.1c02823

他のファイルとリンク

引用スタイル

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author = "Takanori Shibata and Masafumi Kojima and Sahoko Onoda and Mamoru Ito",

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AU - Kojima, Masafumi

AU - Onoda, Sahoko

AU - Ito, Mamoru

N1 - Funding Information: This work was supported by Waseda University Grant for Special Research Projects. Publisher Copyright: ©

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N2 - A chiral Ir-catalyzed reaction of α-aryl-α,β-unsaturated amides with β-substituted acrylates proceeded to give formal conjugate adducts in high yield and ee (up to 99% yield and up to 95% ee). This is the first example of the enantioselective cross-coupling of two different electron-deficient alkenes via vinylic sp2 C-H activation, and polyfunctionalized chiral compounds were obtained.

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