Enantioselective Formal C−H Conjugate Addition of Acetanilides to β-Substituted Acrylates by Chiral Iridium Catalysts

Takanori Shibata*, Masamichi Michino, Hisaki Kurita, Yu Ki Tahara, Kyalo Stephen Kanyiva

*この研究の対応する著者

研究成果: Article査読

32 被引用数 (Scopus)

抄録

The Ir-catalyzed enantioselective reaction of substituted acetanilides with β-substituted α,β-unsaturated esters provided chiral 3,3-disubstituted propanoates in high yield with good-to-excellent enantiomeric excess (up to 99 % ee). This transformation, initiated by sp2C−H bond activation, is the first example of enantioselective formal C−H conjugate addition to β-substituted α,β-unsaturated carbonyl compounds. The starting materials are commercially available and/or readily accessible.

本文言語English
ページ(範囲)88-91
ページ数4
ジャーナルChemistry - A European Journal
23
1
DOI
出版ステータスPublished - 2017 1月 1

ASJC Scopus subject areas

  • 触媒
  • 有機化学

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