Enantioselective preparation of C-ring fragment of cotylenin A via catalytic asymmetric intramolecular cyclopropanation of α-diazo β-keto ester

Kotaro Nagatani, Yunosuke Hoshino, Haruka Tezuka, Masahisa Nakada*

*この研究の対応する著者

    研究成果: Article査読

    7 被引用数 (Scopus)

    抄録

    A synthetic pathway to the C-ring fragment of cotylenin A which emerged from our retrosynthetic analysis of cotylenin A is described. The catalytic asymmetric intramolecular cyclopropanation (CAIMCP) of the α-diazo-β-keto ester bearing 2,4,6-trimethylphenyl group as the ester part has been found to afford the crystalline product with high ee, which allowed to establish the approach to the C-ring fragment which required ten-pot operations. The developed approach would be beneficial to a large scale synthesis of the C-ring fragment for the total synthesis of cotylenin A.

    本文言語English
    ページ(範囲)959-962
    ページ数4
    ジャーナルTetrahedron Letters
    58
    10
    DOI
    出版ステータスPublished - 2017 3月 8

    ASJC Scopus subject areas

    • 生化学
    • 創薬
    • 有機化学

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