Enantioselective Synthesis of Aminoindan Carboxylic Acid Derivatives by the Catalytic Intramolecular [2+2+2] Cycloaddition of Amino-Acid-Tethered Triynes

Yu Ki Tahara, Shuhei Obinata, Kyalo Stephen Kanyiva, Takanori Shibata*, Attila Mándi, Tohru Taniguchi, Kenji Monde

*この研究の対応する著者

研究成果: Article査読

12 被引用数 (Scopus)

抄録

The enantioselective synthesis of aminoindan carboxylic acid (Aic) derivatives was achieved by Rh-catalyzed intramolecular [2+2+2] cycloaddition of amino-acid-tethered triynes. This reaction, along with recrystallization, gave chiral tethered Aic derivatives with excellent enantiomeric excess. Subsequent hydrolysis of the tethered Aic compounds afforded chiral Aic derivatives, which were further transformed into a free Aic and its dimethyl ester in good yields.

本文言語English
ページ(範囲)1405-1413
ページ数9
ジャーナルEuropean Journal of Organic Chemistry
2016
7
DOI
出版ステータスPublished - 2016 3月 1

ASJC Scopus subject areas

  • 物理化学および理論化学
  • 有機化学

フィンガープリント

「Enantioselective Synthesis of Aminoindan Carboxylic Acid Derivatives by the Catalytic Intramolecular [2+2+2] Cycloaddition of Amino-Acid-Tethered Triynes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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