Enantioselective Synthesis of Sulfur-Containing Medium-Ring Heterocycles with Axial Chiralities by Catalytic Intramolecular [2+2+2] Cycloaddition

Akihito Mitake, Toru Fusamae, Stephen Kyalo Kanyiva, Takanori Shibata

研究成果: Article

4 引用 (Scopus)

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The rhodium-catalyzed enantioselective intramolecular cycloaddition of triynes connected by sulfur-containing tethers gave tribenzothiepins and a tribenzodithiocin in high yields with good-to-excellent enantiomeric excesses. The present protocol generated axial chiralities fused with medium-ring heterocycles. In particular, this is the first example of the catalytic and highly enantioselective construction of a tribenzodiheterocin skeleton.

元の言語English
ページ(範囲)7266-7270
ページ数5
ジャーナルEuropean Journal of Organic Chemistry
2017
発行部数48
DOI
出版物ステータスPublished - 2017 12 29

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ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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