End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug: Torpedo-Shaped Peptidic Nanocapsules

Motoki Ueda, Siyoong Seo, Baiju G. Nair, Stefan Müller, Eiki Takahashi, Takashi Arai, Tomonori Iyoda, Shin Ichiro Fujii, Satoshi Tsuneda, Yoshihiro Ito

    研究成果: Article

    1 引用 (Scopus)

    抄録

    Nanomaterial morphology is important for the targeted delivery of drugs to tissues as well as subsequent cellular uptake. Hollow nanotubes composed of peptides, with a diameter of 80 nm and various lengths (100, 200, 300, 600 nm), were successfully capped and sealed with a peptide hemisphere to encapsulate the anticancer drug, cisplatin. The torpedo-shaped nanocapsules with an aspect ratio (length/diameter) of 2.4 showed more rapid cellular uptake and accumulation at the tumor site compared with spherical analogues. Successful delivery of cisplatin to tumors was achieved in a mouse model and tumor growth was efficiently suppressed.

    元の言語English
    ジャーナルACS Nano
    DOI
    出版物ステータスAccepted/In press - 2019 1 1

    Fingerprint

    torpedoes
    Nanocapsules
    encapsulating
    high aspect ratio
    Nanotubes
    Aspect ratio
    Tumors
    hollow
    nanotubes
    drugs
    tumors
    Peptides
    Cisplatin
    Peptide Nanotubes
    peptides
    delivery
    Pharmaceutical Preparations
    hemispheres
    Nanostructured materials
    mice

    Keywords

      ASJC Scopus subject areas

      • Materials Science(all)
      • Engineering(all)
      • Physics and Astronomy(all)

      これを引用

      Ueda, M., Seo, S., Nair, B. G., Müller, S., Takahashi, E., Arai, T., ... Ito, Y. (受理済み/印刷中). End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug: Torpedo-Shaped Peptidic Nanocapsules. ACS Nano. https://doi.org/10.1021/acsnano.8b06189

      End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug : Torpedo-Shaped Peptidic Nanocapsules. / Ueda, Motoki; Seo, Siyoong; Nair, Baiju G.; Müller, Stefan; Takahashi, Eiki; Arai, Takashi; Iyoda, Tomonori; Fujii, Shin Ichiro; Tsuneda, Satoshi; Ito, Yoshihiro.

      :: ACS Nano, 01.01.2019.

      研究成果: Article

      Ueda, Motoki ; Seo, Siyoong ; Nair, Baiju G. ; Müller, Stefan ; Takahashi, Eiki ; Arai, Takashi ; Iyoda, Tomonori ; Fujii, Shin Ichiro ; Tsuneda, Satoshi ; Ito, Yoshihiro. / End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug : Torpedo-Shaped Peptidic Nanocapsules. :: ACS Nano. 2019.
      @article{9c807fada55a44bbb9f43fc6f4e37ba8,
      title = "End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug: Torpedo-Shaped Peptidic Nanocapsules",
      abstract = "Nanomaterial morphology is important for the targeted delivery of drugs to tissues as well as subsequent cellular uptake. Hollow nanotubes composed of peptides, with a diameter of 80 nm and various lengths (100, 200, 300, 600 nm), were successfully capped and sealed with a peptide hemisphere to encapsulate the anticancer drug, cisplatin. The torpedo-shaped nanocapsules with an aspect ratio (length/diameter) of 2.4 showed more rapid cellular uptake and accumulation at the tumor site compared with spherical analogues. Successful delivery of cisplatin to tumors was achieved in a mouse model and tumor growth was efficiently suppressed.",
      keywords = "aspect ratio, cellular uptake, drug delivery carrier, morphology, peptide nanocapsule",
      author = "Motoki Ueda and Siyoong Seo and Nair, {Baiju G.} and Stefan M{\"u}ller and Eiki Takahashi and Takashi Arai and Tomonori Iyoda and Fujii, {Shin Ichiro} and Satoshi Tsuneda and Yoshihiro Ito",
      year = "2019",
      month = "1",
      day = "1",
      doi = "10.1021/acsnano.8b06189",
      language = "English",
      journal = "ACS Nano",
      issn = "1936-0851",
      publisher = "American Chemical Society",

      }

      TY - JOUR

      T1 - End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug

      T2 - Torpedo-Shaped Peptidic Nanocapsules

      AU - Ueda, Motoki

      AU - Seo, Siyoong

      AU - Nair, Baiju G.

      AU - Müller, Stefan

      AU - Takahashi, Eiki

      AU - Arai, Takashi

      AU - Iyoda, Tomonori

      AU - Fujii, Shin Ichiro

      AU - Tsuneda, Satoshi

      AU - Ito, Yoshihiro

      PY - 2019/1/1

      Y1 - 2019/1/1

      N2 - Nanomaterial morphology is important for the targeted delivery of drugs to tissues as well as subsequent cellular uptake. Hollow nanotubes composed of peptides, with a diameter of 80 nm and various lengths (100, 200, 300, 600 nm), were successfully capped and sealed with a peptide hemisphere to encapsulate the anticancer drug, cisplatin. The torpedo-shaped nanocapsules with an aspect ratio (length/diameter) of 2.4 showed more rapid cellular uptake and accumulation at the tumor site compared with spherical analogues. Successful delivery of cisplatin to tumors was achieved in a mouse model and tumor growth was efficiently suppressed.

      AB - Nanomaterial morphology is important for the targeted delivery of drugs to tissues as well as subsequent cellular uptake. Hollow nanotubes composed of peptides, with a diameter of 80 nm and various lengths (100, 200, 300, 600 nm), were successfully capped and sealed with a peptide hemisphere to encapsulate the anticancer drug, cisplatin. The torpedo-shaped nanocapsules with an aspect ratio (length/diameter) of 2.4 showed more rapid cellular uptake and accumulation at the tumor site compared with spherical analogues. Successful delivery of cisplatin to tumors was achieved in a mouse model and tumor growth was efficiently suppressed.

      KW - aspect ratio

      KW - cellular uptake

      KW - drug delivery carrier

      KW - morphology

      KW - peptide nanocapsule

      UR - http://www.scopus.com/inward/record.url?scp=85059803858&partnerID=8YFLogxK

      UR - http://www.scopus.com/inward/citedby.url?scp=85059803858&partnerID=8YFLogxK

      U2 - 10.1021/acsnano.8b06189

      DO - 10.1021/acsnano.8b06189

      M3 - Article

      JO - ACS Nano

      JF - ACS Nano

      SN - 1936-0851

      ER -