End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug

Torpedo-Shaped Peptidic Nanocapsules

Motoki Ueda, Siyoong Seo, Baiju G. Nair, Stefan Müller, Eiki Takahashi, Takashi Arai, Tomonori Iyoda, Shin Ichiro Fujii, Satoshi Tsuneda, Yoshihiro Ito

    研究成果: Article

    1 引用 (Scopus)

    抄録

    Nanomaterial morphology is important for the targeted delivery of drugs to tissues as well as subsequent cellular uptake. Hollow nanotubes composed of peptides, with a diameter of 80 nm and various lengths (100, 200, 300, 600 nm), were successfully capped and sealed with a peptide hemisphere to encapsulate the anticancer drug, cisplatin. The torpedo-shaped nanocapsules with an aspect ratio (length/diameter) of 2.4 showed more rapid cellular uptake and accumulation at the tumor site compared with spherical analogues. Successful delivery of cisplatin to tumors was achieved in a mouse model and tumor growth was efficiently suppressed.

    元の言語English
    ジャーナルACS Nano
    DOI
    出版物ステータスAccepted/In press - 2019 1 1

    Fingerprint

    torpedoes
    Nanocapsules
    encapsulating
    high aspect ratio
    Nanotubes
    Aspect ratio
    Tumors
    hollow
    nanotubes
    drugs
    tumors
    Peptides
    Cisplatin
    Peptide Nanotubes
    peptides
    delivery
    Pharmaceutical Preparations
    hemispheres
    Nanostructured materials
    mice

    ASJC Scopus subject areas

    • Materials Science(all)
    • Engineering(all)
    • Physics and Astronomy(all)

    これを引用

    Ueda, M., Seo, S., Nair, B. G., Müller, S., Takahashi, E., Arai, T., ... Ito, Y. (受理済み/印刷中). End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug: Torpedo-Shaped Peptidic Nanocapsules. ACS Nano. https://doi.org/10.1021/acsnano.8b06189

    End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug : Torpedo-Shaped Peptidic Nanocapsules. / Ueda, Motoki; Seo, Siyoong; Nair, Baiju G.; Müller, Stefan; Takahashi, Eiki; Arai, Takashi; Iyoda, Tomonori; Fujii, Shin Ichiro; Tsuneda, Satoshi; Ito, Yoshihiro.

    :: ACS Nano, 01.01.2019.

    研究成果: Article

    Ueda, Motoki ; Seo, Siyoong ; Nair, Baiju G. ; Müller, Stefan ; Takahashi, Eiki ; Arai, Takashi ; Iyoda, Tomonori ; Fujii, Shin Ichiro ; Tsuneda, Satoshi ; Ito, Yoshihiro. / End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug : Torpedo-Shaped Peptidic Nanocapsules. :: ACS Nano. 2019.
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    AU - Seo, Siyoong

    AU - Nair, Baiju G.

    AU - Müller, Stefan

    AU - Takahashi, Eiki

    AU - Arai, Takashi

    AU - Iyoda, Tomonori

    AU - Fujii, Shin Ichiro

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