Endothelin-1 in the heart during exercise

Seiji Maeda, Takashi Miyauchi, Satoshi Sakai, Tsutomu Kobayashi, Katsutoshi Goto, Yasuro Sugishita, Mitsuo Matsuda*

*この研究の対応する著者

研究成果: Article査読

4 被引用数 (Scopus)

抄録

In addition to its potent vasocontractile effects, endothelin-1 (ET-1) has potent positive inotropic and chronotropic effects on isolated heart muscles in vitro. However, it is not known whether the production of ET-1 in the heart is altered by exercise. In this study we investigated the production of ET-1 in the heart during exercise. Rats performed treadmill running of 45-min duration. Sedentary rats served as controls. Immediately after exercise, the heart was quickly removed. The peptide level of ET-1 in the heart was measured by a sandwich-enzyme immunoassay. The peptide level of ET-1 in the heart was significantly higher in the exercise group than in the control sedentary group. Therefore, we have demonstrated that production of ET-1 in the heart is increased by exercise. The present study suggests that myocardial ET-1 participates in the modulation of cardiac function during exercise.

本文言語English
ページ(範囲)S392-S394
ジャーナルJournal of Cardiovascular Pharmacology
31
SUPPL. 1
DOI
出版ステータスPublished - 1998
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 循環器および心血管医学

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