Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage

Katsuhiko Suzuki, Manabu Totsuka, Shigeyuki Nakaji*, Mutsuo Yamada, Satoru Kudoh, Qiang Liu, Kazuo Sugawara, Kanemitsu Yamaya, Koki Sato

*この研究の対応する著者

研究成果: Article査読

262 被引用数 (Scopus)

抄録

We analyzed adaptation mechanisms regulating systemic inflammatory response of the stressed body by using an experimental challenge of repeated exercise bouts and accompanying muscle inflammation. Eight untrained men bicycled at 90 W for 90 min, 3 days in a row. Exercise induced peripheral neutrophilia with a leftward shift of neutrophil nucleus and neutrophil priming for oxidative activity determined by luminol-dependent chemiluminescence. Plasma growth hormone and interleukin-6 rose significantly after exercise and were closely correlated with the neutrophil responses. Serum creatine kinase and myoglobin levels as muscle damage markers rose after exercise in 'delayed onset' and were closely correlated with the preceding neutrophil responses. These exercise-induced responses were strongest on day 1, but the magnitude gradually decreased with progressive daily exercise. In contrast, the magnitude of catecholamine responses to exercise sessions gradually rose, possibly suppressing neutrophil oxidative responses. These results indicate that stress-induced systemic release of bioactive substances may determine neutrophil mobilization and functional status, which then may affect local tissue damage of susceptible organs.

本文言語English
ページ(範囲)1360-1367
ページ数8
ジャーナルJournal of Applied Physiology
87
4
DOI
出版ステータスPublished - 1999 10月
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 生理学(医学)

フィンガープリント

「Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル