Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease

Novalia Pishesha, Angelina M. Bilate, Marsha C. Wibowo, Nai Jia Huang, Zeyang Li, Rhogerry Dhesycka, Djenet Bousbaine, Hojun Li, Heide C. Patterson, Stephanie K. Dougan, Takeshi Maruyama, Harvey F. Lodish, Hidde L. Ploegh

研究成果: Article査読

78 被引用数 (Scopus)

抄録

Current therapies for autoimmune diseases rely on traditional immunosuppressive medications that expose patients to an increased risk of opportunistic infections and other complications. Immunoregulatory interventions that act prophylactically or therapeutically to induce antigen-specific tolerance might overcome these obstacles. Here we use the transpeptidase sortase to covalently attach diseaseassociated autoantigens to genetically engineered and to unmodified red blood cells as a means of inducing antigen-specific tolerance. This approach blunts the contribution to immunity of major subsets of immune effector cells (B cells, CD4 + and CD8 + T cells) in an antigenspecific manner. Transfusion of red blood cells expressing self-antigen epitopes can alleviate and even prevent signs of disease in experimental autoimmune encephalomyelitis, as well as maintain normoglycemia in a mouse model of type 1 diabetes.

本文言語English
ページ(範囲)3157-3162
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
114
12
DOI
出版ステータスPublished - 2017 3 21
外部発表はい

ASJC Scopus subject areas

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