Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease

Novalia Pishesha, Angelina M. Bilate, Marsha C. Wibowo, Nai Jia Huang, Zeyang Li, Rhogerry Dhesycka, Djenet Bousbaine, Hojun Li, Heide C. Patterson, Stephanie K. Dougan, Takeshi Maruyama, Harvey F. Lodish, Hidde L. Ploegh

研究成果: Article

39 引用 (Scopus)

抜粋

Current therapies for autoimmune diseases rely on traditional immunosuppressive medications that expose patients to an increased risk of opportunistic infections and other complications. Immunoregulatory interventions that act prophylactically or therapeutically to induce antigen-specific tolerance might overcome these obstacles. Here we use the transpeptidase sortase to covalently attach diseaseassociated autoantigens to genetically engineered and to unmodified red blood cells as a means of inducing antigen-specific tolerance. This approach blunts the contribution to immunity of major subsets of immune effector cells (B cells, CD4+ and CD8+T cells) in an antigenspecific manner. Transfusion of red blood cells expressing self-antigen epitopes can alleviate and even prevent signs of disease in experimental autoimmune encephalomyelitis, as well as maintain normoglycemia in a mouse model of type 1 diabetes.

元の言語English
ページ(範囲)3157-3162
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
114
発行部数12
DOI
出版物ステータスPublished - 2017 3 21
外部発表Yes

    フィンガープリント

ASJC Scopus subject areas

  • General

これを引用

Pishesha, N., Bilate, A. M., Wibowo, M. C., Huang, N. J., Li, Z., Dhesycka, R., Bousbaine, D., Li, H., Patterson, H. C., Dougan, S. K., Maruyama, T., Lodish, H. F., & Ploegh, H. L. (2017). Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America, 114(12), 3157-3162. https://doi.org/10.1073/pnas.1701746114