Entrainment of the mouse circadian clock by sub-acute physical and psychological stress

Yu Tahara, Takuya Shiraishi, Yosuke Kikuchi, Atsushi Haraguchi, Daisuke Kuriki, Hiroyuki Sasaki, Hiroaki Motohashi, Tomoko Sakai, Shigenobu Shibata

研究成果: Article

54 引用 (Scopus)

抜粋

The effects of acute stress on the peripheral circadian system are not well understood in vivo. Here, we show that sub-acute stress caused by restraint or social defeat potently altered clock gene expression in the peripheral tissues of mice. In these peripheral tissues, as well as the hippocampus and cortex, stressful stimuli induced time-of-day-dependent phase-advances or -delays in rhythmic clock gene expression patterns; however, such changes were not observed in the suprachiasmatic nucleus, i.e. the central circadian clock. Moreover, several days of stress exposure at the beginning of the light period abolished circadian oscillations and caused internal desynchronisation of peripheral clocks. Stress-induced changes in circadian rhythmicity showed habituation and disappeared with long-term exposure to repeated stress. These findings suggest that sub-acute physical/psychological stress potently entrains peripheral clocks and causes transient dysregulation of circadian clocks in vivo.

元の言語English
記事番号11417
ジャーナルScientific Reports
5
DOI
出版物ステータスPublished - 2015 6 15

ASJC Scopus subject areas

  • General

フィンガープリント Entrainment of the mouse circadian clock by sub-acute physical and psychological stress' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用