Enzyme inhibitors from marine invertebrates

Yoichi Nakao*, Nobuhiro Fusetani

*この研究の対応する著者

研究成果: Review article査読

66 被引用数 (Scopus)

抄録

Marine invertebrates are rich sources of small molecules with unique chemical skeletons and potent bioactivities. Historically, such compounds were discovered mainly through the use of assays for phenotype-oriented activities, such as cytotoxicity or antimicrobial effects. More recently, target-oriented searches for bioactive substances, as exemplified by enzyme inhibitors, have become much more common, given a growing need for small-molecule inhibitors essential for studies of complex processes at the interface of chemistry and biology. In this review, selected enzyme inhibitors from marine invertebrates are presented.

本文言語English
ページ(範囲)689-710
ページ数22
ジャーナルJournal of Natural Products
70
4
DOI
出版ステータスPublished - 2007 4 1
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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