Epigenetics: The study of embryonic stem cells by restriction landmark genomic scanning

Naka Hattori, Kunio Shiota

研究成果: Short survey

5 引用 (Scopus)

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During mammalian development, it is essential that the proper epigenetic state is established across the entire genome in each differentiated cell. To date, little is known about the mechanism for establishing epigenetic modifications of individual genes during the course of cellular differentiation. Genome-wide DNA methylation analysis of embryonic stem cells by restriction landmark genomic scanning provides information about cell type- and tissue-specific DNA methylation profiles at tissue-specific methylated regions associated with developmental processes. It also sheds light on DNA methylation alterations following fetal exposure to chemical agents. In addition, analysis of embryonic stem cells deficient in epigenetic regulators will contribute to revealing the mechanism for establishing DNA methylation profiles and the interplay between DNA methylation and other epigenetic modifications.

元の言語English
ページ(範囲)1624-1630
ページ数7
ジャーナルFEBS Journal
275
発行部数8
DOI
出版物ステータスPublished - 2008 4
外部発表Yes

ASJC Scopus subject areas

  • Biochemistry

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