抄録
Micro/nano-bubbles are practical nanomaterials designed to increase the gas content in liquids. We attempted to use oxygen micro/nano-bubble dispersions as an oxygen-rich liquid as a means for total liquid ventilation. To determine the oxygen content in the bubble dispersion, a new method based on a spectrophotometric change between oxy- and deoxy-hemoglobin was established. The oxygen micro/nano-bubble dispersion was supplied to an experimental total ventilation liquid in anesthetic rats. Though the amount of dissolving oxygen was as low as 6 mg/L in physiological saline, the oxygen content in the oxygen micro/nano-bubble dispersion was increased to 45 mg/L. The positive correlation between the oxygen content and the life-saving time under liquid ventilation clearly indicates that the life-saving time is prolonged by increasing the oxygen content in the oxygen micro/nano-bubble dispersion. This is the first report indicating that the oxygen micro/nano-bubbles containing a sufficient amount of oxygen are useful in producing oxygen-rich liquid for the process of liquid ventilation.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 220-227 |
| ページ数 | 8 |
| ジャーナル | Journal of Artificial Organs |
| 巻 | 18 |
| 号 | 3 |
| DOI | |
| 出版ステータス | Published - 2015 9月 4 |
ASJC Scopus subject areas
- 医学（その他）
- 生体材料
- 生体医工学
- 循環器および心血管医学