Estimating the number of double-strand breaks formed during meiosis from partial observation

Hiroshi Toyoizumi*, Hideo Tsubouchi

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Analyzing the basic mechanism of DNA double-strand breaks (DSB) formation during meiosis is important for understanding sexual reproduction and genetic diversity. The location and amount of meiotic DSBs can be examined by using a common molecular biological technique called Southern blotting, but only a subset of the total DSBs can be observed; only DSB fragments still carrying the region recognized by a Southern blot probe are detected. With the assumption that DSB formation follows a nonhomogeneous Poisson process, we propose two estimators of the total number of DSBs on a chromosome: (1) an estimator based on the Nelson-Aalen estimator, and (2) an estimator based on a record value process. Further, we compared their asymptotic accuracy.

本文言語English
ページ(範囲)1277-1283
ページ数7
ジャーナルJournal of Computational Biology
19
12
DOI
出版ステータスPublished - 2012 12 1

ASJC Scopus subject areas

  • モデリングとシミュレーション
  • 分子生物学
  • 遺伝学
  • 計算数学
  • 計算理論と計算数学

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