Estimation of Kinetics for Batch Cooling Crystallization by Focused-Beam Reflectance Measurements

Joi Unno, Hiroki Kawase, Reiya Kaneshige, Izumi Hirasawa

研究成果: Article

2 引用 (Scopus)

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Numerical simulation of the seeded batch cooling crystallization process of active pharmaceutical ingredients was performed. Crystal size distribution was observed by focused-beam reflectance measurements and concentration by simultaneous Fourier transform infrared spectroscopy. First, kinetic parameters were estimated. Nucleation rate coefficient and order were estimated from the linear regression equation between cooling rate and metastable zone width. The remaining parameters were estimated from the evaluation function. Then, the numerical simulation was performed by utilizing the method of moments. Finally, observed data were compared with simulated data. The simulated values of mean mass size corresponded reasonably with the observed ones.

元の言語English
ジャーナルChemical Engineering and Technology
DOI
出版物ステータスPublished - 2019 1 1

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

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