Estimation of Kinetics for Batch Cooling Crystallization by Focused-Beam Reflectance Measurements

Joi Unno*, Hiroki Kawase, Reiya Kaneshige, Izumi Hirasawa

*この研究の対応する著者

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Numerical simulation of the seeded batch cooling crystallization process of active pharmaceutical ingredients was performed. Crystal size distribution was observed by focused-beam reflectance measurements and concentration by simultaneous Fourier transform infrared spectroscopy. First, kinetic parameters were estimated. Nucleation rate coefficient and order were estimated from the linear regression equation between cooling rate and metastable zone width. The remaining parameters were estimated from the evaluation function. Then, the numerical simulation was performed by utilizing the method of moments. Finally, observed data were compared with simulated data. The simulated values of mean mass size corresponded reasonably with the observed ones.

本文言語English
ページ(範囲)1428-1434
ページ数7
ジャーナルChemical Engineering and Technology
42
7
DOI
出版ステータスPublished - 2019 7

ASJC Scopus subject areas

  • 化学 (全般)
  • 化学工学(全般)
  • 産業および生産工学

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