Bestimmung des regionalen zerebralen Blutflusses mit N-Isopropyl-p-Iod-123-Iodamphetamin mittels Akquisitionsdaten von Lunge und Gehirn Eine verbesserte nicht-invasive Abschätzung

S. Abe, Katsuhiko Kato*, Y. Takahashi, N. Fujita, M. Ikeda, N. Ota, Y. Kajita, S. Yamamoto, S. Naganawa

*この研究の対応する著者

研究成果: Article査読

抄録

Aim: Previously, we devised a method for estimating 123I labeled N-isopropyl-p-iodo -amphetamine ( 123I IMP) arterial blood activity at 10 minutes after intravenous injection of 123I IMP (Ca10) without any blood sampling using 123I IMP autoradiography (ARG) acquisition data, and verified its usefulness for quantification of regional cerebral blood flow (rCBF). In this study, we attempted to develop an improved noninvasive method for estimating rCBF. Patients, methods: 123I IMP studies with 23 patients and 15O-H2O positron emission tomography (PET) ARG studies with 20 patients were evaluated. Multiple regression analysis was used to estimate an integral of the arterial blood counts during the time after injection of 123I (∫Ca) using parameters from the time series of the lung counts and brain counts as the explanatory variables and the fraction [brain single-photon emission computed tomography (SPECT) average count / the mean of rCBFs (mean CBF) measured by 15O-H2O PET ARG method] as the objective variable. Results: The regression equation was as follows: Estimated ∫Ca = (7.09×10–3 · Cb12) – (1.57×10–4 · Cbpre SPECT) + (9.48×10–5 · CbpostSPECT) + (1.35×10–4 · L15) – (6.95×10–4 · L33) + (7.61×10–4 · L81) – (0.417), where Cb12: brain count at 12 minutes, Cbpre-SPECT: brain count before SPECT, Cbpost-SPECT: brain count after SPECT, L15, L33, and L81: lung count at 15, 33, and 81 seconds, respectively. The mean CBF values (ml/min/100g) calculated using the estimated ∫Ca values more closely correlated with those measured by 15O-H2O PET ARG method (r = 0.833, p < 0.01) than those obtained by our previous method (r = 0.590, p < 0.01). Conclusion:The rCBFs obtained by this method approximated more accurately to the values measured by 15O-H2O PET ARG method than those obtained by our previous method.

寄稿の翻訳タイトルEstimation of regional cerebral blood flow using N-isopropyl-p-123I iodo amphetamine acquisition data from the lungs and brain: An improved non-invasive technique
本文言語German
ページ(範囲)221-226
ページ数6
ジャーナルNuklearmedizin
53
6
DOI
出版ステータスPublished - 2014
外部発表はい

ASJC Scopus subject areas

  • 放射線学、核医学およびイメージング

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