Estrogen modulates central and peripheral responses to cold in female rats

Yuki Uchida, Masumi Kano, Saki Yasuhara, Akiko Kobayashi, Ken Tokizawa, Kei Nagashima*

*この研究の対応する著者

研究成果: Article査読

19 被引用数 (Scopus)

抄録

The aim of this study was to determine whether estrogen modulates central and peripheral responses to cold in female rats. In ovariectomized female rats with and without administered estrogen [E2 (+) and E2 (-), respectively], the counts of cFos-immunoreactive cells in the medial preoptic nucleus (MPO) and dorsomedial hypothalamic nucleus (DMH) in the hypothalamus were greater in the E2 (+) rats than in the E2 (-) rats at 5°C. Examination of the response of normal female rats to exposure to 5°C at different phases of the estrus cycle revealed that counts of cFos-immunoreactive cells in the MPO, DMH, and posterior hypothalamus and the level of uncoupling protein 1 mRNA in the brown adipose tissues were greater in the proestrus phase than on day 1 of the diestrus phase. This result was linked to the level of plasma estrogen. The body temperature during cold exposure was higher in the E2 (+) rats than in the E2 (-) rats and was also higher in the proestrus phase than on day 1 of the diestrus phase. We conclude that estrogen may affect central and peripheral responses involved in thermoregulation in the cold.

本文言語English
ページ(範囲)151-160
ページ数10
ジャーナルJournal of Physiological Sciences
60
2
DOI
出版ステータスPublished - 2010 3

ASJC Scopus subject areas

  • 生理学

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