Evaluation of a new solution containing trehalose for twenty-hour canine lung preservation

Naohiro Kajiwara*, Masahiko Taguchi, Hiroshi Saito, Shin Nakajima, Aeru Hayashi, Norihiko Kawate, Chimori Konaka, Hiromi Wada, Harubumi Kato

*この研究の対応する著者

研究成果査読

4 被引用数 (Scopus)

抄録

We examined the efficacy of two new preservation solutions containing trehalose - an extracellular type (ET-K) of solution and an intracellular type (IT-K) of solution - in relation to that of Euro-Collins (EC) solution in 20-h canine lung preservation. Canine lungs were flushed with one of the three solutions (n = 5 for each solution) after pretreatment with PGE1 (20 μg/kg) and were stored for 20 h at 4°C. The left lungs were transplanted and evaluated to 6 h post transplant. In the ET-K group, the arterial oxygen tension after reperfusion was significantly higher than in the IT-K and EC groups. The pulmonary vascular resistance, wet/dry weight ratio, and histological evaluation of each transplanted lung in the ET-K group were also better than in the IT-K and EC groups. This indicates that ET-K solution is useful for 20-h preservation of canine lung grafts.

本文言語English
ページ(範囲)194-200
ページ数7
ジャーナルTransplant International
9
3
DOI
出版ステータスPublished - 1996 5
外部発表はい

ASJC Scopus subject areas

  • 移植

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