Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells

Youichi Nakao, Genta Narazaki, Takuhiro Hoshino, Satoko Maeda, Minoru Yoshida, Hiroshi Maejima, Jun K. Yamashita

    研究成果: Article

    24 引用 (Scopus)

    抄録

    Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.

    元の言語English
    ページ(範囲)2982-2984
    ページ数3
    ジャーナルBioorganic and Medicinal Chemistry Letters
    18
    発行部数9
    DOI
    出版物ステータスPublished - 2008 5 1

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    Induced Pluripotent Stem Cells
    Stem cells
    Blood Vessels
    Porifera
    Cell Biology
    Stem Cells
    Molecules
    In Vitro Techniques
    azumamide E

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Organic Chemistry
    • Drug Discovery
    • Pharmaceutical Science

    これを引用

    Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. / Nakao, Youichi; Narazaki, Genta; Hoshino, Takuhiro; Maeda, Satoko; Yoshida, Minoru; Maejima, Hiroshi; Yamashita, Jun K.

    :: Bioorganic and Medicinal Chemistry Letters, 巻 18, 番号 9, 01.05.2008, p. 2982-2984.

    研究成果: Article

    Nakao, Youichi ; Narazaki, Genta ; Hoshino, Takuhiro ; Maeda, Satoko ; Yoshida, Minoru ; Maejima, Hiroshi ; Yamashita, Jun K. / Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. :: Bioorganic and Medicinal Chemistry Letters. 2008 ; 巻 18, 番号 9. pp. 2982-2984.
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    AU - Maeda, Satoko

    AU - Yoshida, Minoru

    AU - Maejima, Hiroshi

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