Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Dora Abraham; Janos Feher; Gian Luca Scuderi; Dora Szabo; Arpad Dobolyi; Melinda Cservenak; Janos Juhasz; Balazs Ligeti; Sandor Pongor; Mari Carmen Gomez-Cabrera; Jose Vina; Mitsuru Higuchi; Katsuhiro Suzuki; Istvan Boldogh; Zsolt Radak

doi:10.1016/j.exger.2018.12.005

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Dora Abraham, Janos Feher, Gian Luca Scuderi, Dora Szabo, Arpad Dobolyi, Melinda Cservenak, Janos Juhasz, Balazs Ligeti, Sandor Pongor, Mari Carmen Gomez-Cabrera, Jose Vina, Mitsuru Higuchi, Katsuhiro Suzuki, Istvan Boldogh, Zsolt Radak^*

^*この研究の対応する著者

研究成果: Article › 査読

83 被引用数 (Scopus)

抄録

It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1^TG). APP/PS1^TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p < 0.05), and this group of bacteria was significantly elevated in the microbiome of the APP/PS1^TG mice compared to the wild type. L. johnsonii levels positively correlated with the beta amyloid content and area. Data revealed that exercise and probiotic treatment can decrease the progress of Alzheimer's Disease and the beneficial effects could be partly mediated by alteration of the microbiome.

本文言語	English
ページ（範囲）	122-131
ページ数	10
ジャーナル	Experimental Gerontology
巻	115
DOI	https://doi.org/10.1016/j.exger.2018.12.005
出版ステータス	Published - 2019 1月

ASJC Scopus subject areas

生化学
加齢科学
分子生物学
遺伝学
内分泌学
細胞生物学

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10.1016/j.exger.2018.12.005

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Abraham, D., Feher, J., Scuderi, G. L., Szabo, D., Dobolyi, A., Cservenak, M., Juhasz, J., Ligeti, B., Pongor, S., Gomez-Cabrera, M. C., Vina, J., Higuchi, M., Suzuki, K., Boldogh, I., & Radak, Z. (2019). Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome. Experimental Gerontology, 115, 122-131. https://doi.org/10.1016/j.exger.2018.12.005

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice : Role of microbiome. / Abraham, Dora; Feher, Janos; Scuderi, Gian Luca; Szabo, Dora; Dobolyi, Arpad; Cservenak, Melinda; Juhasz, Janos; Ligeti, Balazs; Pongor, Sandor; Gomez-Cabrera, Mari Carmen; Vina, Jose; Higuchi, Mitsuru; Suzuki, Katsuhiro; Boldogh, Istvan; Radak, Zsolt.

In: Experimental Gerontology, Vol. 115, 01.2019, p. 122-131.

研究成果: Article › 査読

Abraham, D, Feher, J, Scuderi, GL, Szabo, D, Dobolyi, A, Cservenak, M, Juhasz, J, Ligeti, B, Pongor, S, Gomez-Cabrera, MC, Vina, J, Higuchi, M, Suzuki, K, Boldogh, I & Radak, Z 2019, 'Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome', Experimental Gerontology, vol. 115, pp. 122-131. https://doi.org/10.1016/j.exger.2018.12.005

Abraham, Dora ; Feher, Janos ; Scuderi, Gian Luca ; Szabo, Dora ; Dobolyi, Arpad ; Cservenak, Melinda ; Juhasz, Janos ; Ligeti, Balazs ; Pongor, Sandor ; Gomez-Cabrera, Mari Carmen ; Vina, Jose ; Higuchi, Mitsuru ; Suzuki, Katsuhiro ; Boldogh, Istvan ; Radak, Zsolt. / Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice : Role of microbiome. In: Experimental Gerontology. 2019 ; Vol. 115. pp. 122-131.

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abstract = "It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1TG). APP/PS1TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p < 0.05), and this group of bacteria was significantly elevated in the microbiome of the APP/PS1TG mice compared to the wild type. L. johnsonii levels positively correlated with the beta amyloid content and area. Data revealed that exercise and probiotic treatment can decrease the progress of Alzheimer's Disease and the beneficial effects could be partly mediated by alteration of the microbiome.",

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note = "Funding Information: This study was supported by OTKA ( 112810 ) and National Excellence Program ( 126823 ) grants awarded to Z.R. Authors acknowledge the assistance of Professor A.W. Taylor in the preparation of the manuscript. Publisher Copyright: {\textcopyright} 2018",

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AU - Higuchi, Mitsuru

AU - Suzuki, Katsuhiro

AU - Boldogh, Istvan

AU - Radak, Zsolt

N1 - Funding Information: This study was supported by OTKA ( 112810 ) and National Excellence Program ( 126823 ) grants awarded to Z.R. Authors acknowledge the assistance of Professor A.W. Taylor in the preparation of the manuscript. Publisher Copyright: © 2018

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Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

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