Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice

Tímea Téglás, Dóra Ábrahám, Mátyás Jókai, Saki Kondo, Rezieh Mohammadi, János Fehér, Dóra Szabó, Marta Wilhelm, Zsolt Radák

研究成果: Article査読

抄録

It has been demonstrated that physical exercise and probiotic supplementation delay the progress of Alzheimer’s Disease (AD) in male APP/PS1TG mice. However, it has also been suggested that both exercise and AD have systemic effects. We have studied the effects of exercise training and probiotic treatment on microbiome and biochemical signalling proteins in the liver. The results suggest that liver is under oxidative stress, since SOD2 levels of APP/PS1 mice were decreased when compared to a wild type of mice. Exercise training prevented this decrease. We did not find significant changes in COX4, SIRT3, PGC-1a or GLUT4 levels, while the changes in pAMPK/AMPK, pmTOR/mTOR, pS6/S6 and NRF2 levels were randomly modulated. The data suggest that exercise and probiotics-induced changes in microbiome do not strongly affect mitochondrial density or protein synthesis-related AMPK/mTOR/S6 pathways in the liver of these animals.

本文言語English
ページ(範囲)807-815
ページ数9
ジャーナルBiogerontology
21
6
DOI
出版ステータスPublished - 2020 12 1

ASJC Scopus subject areas

  • Ageing
  • Gerontology
  • Geriatrics and Gerontology

フィンガープリント 「Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル