Exercise Training Attenuates the Dysregulated Expression of Adipokines and Oxidative Stress in White Adipose Tissue

Takuya Sakurai, Junetsu Ogasawara, Ken Shirato, Tetsuya Izawa, Shuji Oh-Ishi, Yoshinaga Ishibashi, Zsolt Radak, Hideki Ohno, Takako Kizaki

研究成果: Article

17 引用 (Scopus)

抄録

Obesity-induced inflammatory changes in white adipose tissue (WAT), which caused dysregulated expression of inflammation-related adipokines involving tumor necrosis factor-α and monocyte chemoattractant protein-1, contribute to the development of insulin resistance. Moreover, current literature reports state that WAT generates reactive oxygen species (ROS), and the enhanced production of ROS in obese WAT has been closely associated with the dysregulated expression of adipokines in WAT. Therefore, the reduction in excess WAT and oxidative stress that results from obesity is thought to be one of the important strategies in preventing and improving lifestyle-related diseases. Exercise training (TR) not only brings about a decrease in WAT mass but also attenuates obesity-induced dysregulated expression of the adipokines in WAT. Furthermore, some reports indicate that TR affects the generation of oxidative stress in WAT. This review outlines the impact of TR on the expression of inflammation-related adipokines and oxidative stress in WAT.

元の言語English
記事番号9410954
ジャーナルOxidative Medicine and Cellular Longevity
2017
DOI
出版物ステータスPublished - 2017 1 1
外部発表Yes

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White Adipose Tissue
Adipokines
Oxidative stress
Oxidative Stress
Exercise
Tissue
Obesity
Reactive Oxygen Species
Inflammation
Chemokine CCL2
Insulin Resistance
Life Style
Tumor Necrosis Factor-alpha
Insulin

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology

これを引用

Exercise Training Attenuates the Dysregulated Expression of Adipokines and Oxidative Stress in White Adipose Tissue. / Sakurai, Takuya; Ogasawara, Junetsu; Shirato, Ken; Izawa, Tetsuya; Oh-Ishi, Shuji; Ishibashi, Yoshinaga; Radak, Zsolt; Ohno, Hideki; Kizaki, Takako.

:: Oxidative Medicine and Cellular Longevity, 巻 2017, 9410954, 01.01.2017.

研究成果: Article

Sakurai, T, Ogasawara, J, Shirato, K, Izawa, T, Oh-Ishi, S, Ishibashi, Y, Radak, Z, Ohno, H & Kizaki, T 2017, 'Exercise Training Attenuates the Dysregulated Expression of Adipokines and Oxidative Stress in White Adipose Tissue', Oxidative Medicine and Cellular Longevity, 巻. 2017, 9410954. https://doi.org/10.1155/2017/9410954
Sakurai, Takuya ; Ogasawara, Junetsu ; Shirato, Ken ; Izawa, Tetsuya ; Oh-Ishi, Shuji ; Ishibashi, Yoshinaga ; Radak, Zsolt ; Ohno, Hideki ; Kizaki, Takako. / Exercise Training Attenuates the Dysregulated Expression of Adipokines and Oxidative Stress in White Adipose Tissue. :: Oxidative Medicine and Cellular Longevity. 2017 ; 巻 2017.
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abstract = "Obesity-induced inflammatory changes in white adipose tissue (WAT), which caused dysregulated expression of inflammation-related adipokines involving tumor necrosis factor-α and monocyte chemoattractant protein-1, contribute to the development of insulin resistance. Moreover, current literature reports state that WAT generates reactive oxygen species (ROS), and the enhanced production of ROS in obese WAT has been closely associated with the dysregulated expression of adipokines in WAT. Therefore, the reduction in excess WAT and oxidative stress that results from obesity is thought to be one of the important strategies in preventing and improving lifestyle-related diseases. Exercise training (TR) not only brings about a decrease in WAT mass but also attenuates obesity-induced dysregulated expression of the adipokines in WAT. Furthermore, some reports indicate that TR affects the generation of oxidative stress in WAT. This review outlines the impact of TR on the expression of inflammation-related adipokines and oxidative stress in WAT.",
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AU - Oh-Ishi, Shuji

AU - Ishibashi, Yoshinaga

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