Exercise Training Attenuates the Dysregulated Expression of Adipokines and Oxidative Stress in White Adipose Tissue

Takuya Sakurai, Junetsu Ogasawara, Ken Shirato, Tetsuya Izawa, Shuji Oh-Ishi, Yoshinaga Ishibashi, Zsolt Radak, Hideki Ohno, Takako Kizaki

研究成果: Article

23 引用 (Scopus)

抜粋

Obesity-induced inflammatory changes in white adipose tissue (WAT), which caused dysregulated expression of inflammation-related adipokines involving tumor necrosis factor-α and monocyte chemoattractant protein-1, contribute to the development of insulin resistance. Moreover, current literature reports state that WAT generates reactive oxygen species (ROS), and the enhanced production of ROS in obese WAT has been closely associated with the dysregulated expression of adipokines in WAT. Therefore, the reduction in excess WAT and oxidative stress that results from obesity is thought to be one of the important strategies in preventing and improving lifestyle-related diseases. Exercise training (TR) not only brings about a decrease in WAT mass but also attenuates obesity-induced dysregulated expression of the adipokines in WAT. Furthermore, some reports indicate that TR affects the generation of oxidative stress in WAT. This review outlines the impact of TR on the expression of inflammation-related adipokines and oxidative stress in WAT.

元の言語English
記事番号9410954
ジャーナルOxidative Medicine and Cellular Longevity
2017
DOI
出版物ステータスPublished - 2017 1 1
外部発表Yes

    フィンガープリント

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology

これを引用

Sakurai, T., Ogasawara, J., Shirato, K., Izawa, T., Oh-Ishi, S., Ishibashi, Y., Radak, Z., Ohno, H., & Kizaki, T. (2017). Exercise Training Attenuates the Dysregulated Expression of Adipokines and Oxidative Stress in White Adipose Tissue. Oxidative Medicine and Cellular Longevity, 2017, [9410954]. https://doi.org/10.1155/2017/9410954