Existence of nuclear-encoded 5S-rRNA in bovine mitochondria

Shigeo Yoshionari, Tomohiro Koike, Takashi Yokogawa, Kazuya Nishikawa, Takuya Ueda*, Kinichiro Miura, Kimitsuna Watanabe

*この研究の対応する著者

研究成果: Article査読

55 被引用数 (Scopus)

抄録

A number of proteins functioning in mitochondria are synthesized in the cytoplasm and imported into the mitochondria via specific transport systems. In mammals, on the contrary, mitochondrial membranes have generally been considered to be impermeable to nucleic acids. However, here we show that an RNA with 120 nucleotides, the sequence of which is identical to that of the nuclear-encoded 5S RNA, exists in bovine mitochondria, although the mitochondrial genome encodes no 5S RNA gene. This RNA molecule was found to be retained in purified bovine mitochondria as well as in the mitoplasts, even after extensive treatment with an RNase, demonstrating that the 5S RNA is actually located inside the mitochondrial inner membrane. The 5S rRNA molecule was also shown to exist in mitochondria from rabbit and chicken.

本文言語English
ページ(範囲)137-142
ページ数6
ジャーナルFEBS Letters
338
2
DOI
出版ステータスPublished - 1994 1月 31
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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