Extended light exposure suppresses nocturnal increases in cytotoxic activity of splenic natural killer cells in rats

Katsutaka Oishi*, Kentaro Shibusawa, Hitosa Kakazu, Takao Kuriyama, Naoki Ohkura, Kazuhiko Machida

*この研究の対応する著者

研究成果: Article査読

14 被引用数 (Scopus)

抄録

To understand light-induced immune modulation in vivo, we evaluated the effect of nocturnal light exposure on splenic natural killer (NK) cell activity in rats. Nocturnal increases in the number and cytotoxic activity of NK cells were significantly suppressed under extended light exposure. Nocturnal increases in serum corticosterone levels were also suppressed by light exposure, suggesting that the light exposure-induced decrease in NK cell functions was not due to stress-induced glucocorticoid secretion in rats. These results suggest that nocturnal light exposure could profoundly affect NK cell functions perhaps through eye-brain hormonal modulation.

本文言語English
ページ(範囲)29-35
ページ数7
ジャーナルBiological Rhythm Research
37
1
DOI
出版ステータスPublished - 2006 2 1

ASJC Scopus subject areas

  • 農業および生物科学(その他)
  • 生理学

フィンガープリント

「Extended light exposure suppresses nocturnal increases in cytotoxic activity of splenic natural killer cells in rats」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル