F 1-ATPase: A prototypical rotary molecular motor

Kazuhiko Kinosita*

*この研究の対応する著者

    研究成果: Chapter

    9 被引用数 (Scopus)

    抄録

    F 1-ATPase, the soluble portion of ATP synthase, has been shown to be a rotary molecular motor in which the central γ subunit rotates inside the cylinder made of α 3β 3 subunits. The rotation is powered by ATP hydrolysis in three catalytic sites, and reverse rotation of the γ subunit by an external force leads to ATP synthesis in the catalytic sites. Here I look back how our lab became involved in the study of this marvelous rotary machine, and discuss some aspects of its rotary mechanism while confessing we are far from understanding. This article is a very personal essay, not a scientific review, for this otherwise viral machines book.

    本文言語English
    ホスト出版物のタイトルAdvances in Experimental Medicine and Biology
    ページ5-16
    ページ数12
    726
    DOI
    出版ステータスPublished - 2012

    出版物シリーズ

    名前Advances in Experimental Medicine and Biology
    726
    ISSN(印刷版)00652598

    ASJC Scopus subject areas

    • 生化学、遺伝学、分子生物学(全般)
    • 医学(全般)

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